Thursday, June 27, 2013

New study on popular prostate cancer protein provides insight into disease progression

June 25, 2013 ? Researchers at the Cedars-Sinai Samuel Oschin Comprehensive Cancer Institute have uncovered for the first time the vital role a popular protein plays in the stroma, the cell-lined area outside of a prostate tumor.

Researchers have long understood the function of the protein, Caveolin-1 (Cav-1), in prostate cancer, including its role in treatment resistance and disease aggressiveness. However, prior to this study, little was known about the role of Cav-1 within the stroma.

The study, published in the Journal of Pathology, found that a decreased level of the Cav-1 protein in the stroma indicated tumor progression -- a function opposite to the known role of Cav-1 within a tumor. Inside the tumor, an increased level of this protein signifies tumor progression. These human tumor findings suggest that patients whose prostate tumor is surrounded by a stroma with decreased levels of the Cav-1 protein may have an overall worse prognosis and a higher chance of disease relapse.

"How a prostate tumor communicates with its microenvironment, or stroma, is a vital process we need to understand to assess the aggressiveness of a patient's disease and potential response to treatment," said Dolores Di Vizio, MD, PhD, associate professor in the Urologic Oncology Research Program and senior investigator of the study. "This research suggests that the cells surrounding a prostate tumor are equally as important as the tumor itself in helping understand the complexity of a man's disease. This early-stage research may provide a new, future marker that may ultimately aid diagnosis and treatment, and personalize prostate cancer therapy."

In addition to understanding the role of Cav-1 in the tumor microenvironment, researchers discovered that the loss of Cav-1 causes an increase of cholesterol in the stroma. Previous research findings suggest that cholesterol levels are related to aggressive prostate cancer, but cholesterol's role had never been evaluated within the stroma.

"Cholesterol has been shown to be a driver of prostate cancer progression," said Di Vizio. "For the first time in prostate cancer research, we found that when levels of Cav-1 decrease in the stroma, both cholesterol and androgens increase. This finding may partly explain a resistance to traditional treatments."

Though the findings are preliminary, the Cedars-Sinai researchers Di Vizio, Michael Freeman, PhD, vice chair of research in the Department of Surgery and professor/director of the Cancer Biology Program at the Samuel Oschin Comprehensive Cancer Institute, and post-doctoral fellows Matteo Morello, PhD, and Sungyong You, PhD, will continue evaluating the role of the Caveolin-1 protein in the stroma and its potential end benefit in patients.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/most_popular/~3/VE9UPKMFmBY/130625092006.htm

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Wednesday, June 26, 2013

2013 NBA Draft Busts And Steals: Beware Of Nerlens Noel

The NBA Draft is almost here and we still don't know for sure who the top overall pick will be.

Kentucky's Nerlens Noel is my prediction, but the fact that there is no clear No. 1 choice is news by itself. Yet while this particular draft may lack star power, it does offer value, especially in the middle-to-late first round where a number of potential sleepers will be.

And, as always, we cannot forget about the busts as well. Let's take a look.

Busts

Nerlens Noel, C, Kentucky

He's not as raw as the Thunder's Hasheem Thabeet and he's a more fluid athlete, but for a guy who's likely to be chosen first overall, Noel reminds me of the former second pick. This is not a good thing. There are concerns about Noel recovering from an ACL injury, and the fact that he's lost 25 lbs. from his very slight frame. While Noel is a terrific shot-blocker and highly active center, the lack of sheer basketball acumen and the fact that he is so raw offensively are huge scares. During his limited time at Kentucky, he didn't display a consistent touch outside the paint and showed that he could be a real work-in-progress as a pick-and-roll player. The dearth of big men in this draft has elevated his value, but it's still tough to justify taking Noel in the top three.

Michael Carter-Williams, PG, Syracuse

Carter-Williams has all the measurements on paper. He is 6-foot-6 and an explosive leaper who can flat out dish the rock. But NBA point guards these days have to score and have to be able to shoot the three out of a pick-and-roll, two areas where he has shown zero ability. Watch Carter-Williams and he will jump off the page with "flash plays," but something is definitely missing and I would stay away, even in the mid-teens. One scout told me that Jim Boeheim didn't love him either. For a guy with his type of talent, MCW doesn't impact the game the way he should.

Anthony Bennett, F, UNLV

Bennett is hard to evaluate because he played just one season in college and has a high ceiling. He can really finish above the rim and has displayed some nice versatility. But he's really going to struggle in the half-court NBA offense and quite honestly, I wonder what his true pro position is. He could play the three or the four, but he reminds me a lot of the Timerwolves' Derrick Williams, who was actually better when he left Arizona (scored more and was more efficient), but I don't believe he will be able to score with the same ease he did in college.

Steals

Dennis Schroeder, PG, Germany

The 6-foot-2 Schroeder really helped himself at the Nike Hoops Summit, where he displayed an elite first step and real ability to run screen-and-roll. He is still just 19 and a little wild, but his 6-foot-8 wingspan and tremendous lateral quickness make him special. He is also a hounding, on-ball defender and although he's raw, could become the best point guard out of the class because of his pure instincts on both sides of the floor.

2013 nba draft

Dennis Schroeder, 19, of Germany, has a wonderful blend of quickness and explosive ability from the point guard position. (Getty Images)

Giannis Antetokounmpo, F, Greece

Like Schroeder, Antetokounmpo has an incredible upside and will also need time to develop physically. At 6-foot-9, he possesses excellent versatility because of his ability to handle the ball and score in the open floor, as well as facilitate for teammates. He still gets pushed around and struggles with a lack of strength, but Antetokounmpo is an elite talent who could have been a surefire top 10 pick in a year had he gone to college in the states. Give him three NBA seasons and he could become the steal of this draft.

Jackie Carmichael, PF, Illinois State

Guards Erick Green (Virginia Tech) and Ray McCallum Jr. (Detroit) are sleepers, but Carmichael is about as sure a thing as you can get in the 30s or 40s, and exactly why this draft is so interesting. He has an extremely high motor and a real knack for rebounding. While limited offensively, Carmichael offers high value because he has zero ego and will compete every night -- for 5 minutes or 20. He's the kind of glue-guy every good team needs, but very few actually possess.

Email me at jordan.schultz@huffingtonpost.com or ask me questions about anything sports-related at @Schultz_Report. Also, be sure and catch my NBC Sports Radio show, Kup and Schultz, which airs Sunday mornings from 9-12 ET, right here.

Related on HuffPost:

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Source: http://www.huffingtonpost.com/2013/06/26/2013-nba-draft_n_3504452.html

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Ouya looks to make a dent in game console market

Julie Uhrman, chief executive of Android game console maker Ouya, is interviewed in New York, Tuesday, June 25, 2013. Ouya, that went on sale Tuesday for $99, aims to challenge the dominance of the Xboxes, Nintendos and PlayStations of the world. The launch follows a successful funding campaign through the group-fundraising site Kickstarter, but it's unclear whether the console will enjoy broader success. (AP Photo/Richard Drew)

Julie Uhrman, chief executive of Android game console maker Ouya, is interviewed in New York, Tuesday, June 25, 2013. Ouya, that went on sale Tuesday for $99, aims to challenge the dominance of the Xboxes, Nintendos and PlayStations of the world. The launch follows a successful funding campaign through the group-fundraising site Kickstarter, but it's unclear whether the console will enjoy broader success. (AP Photo/Richard Drew)

Julie Uhrman, chief executive of Android game console maker Ouya, describes the controller of the new console, during an an interview in New York, Tuesday, June 25, 2013. Ouya, that went on sale Tuesday for $99, aims to challenge the dominance of the Xboxes, Nintendos and PlayStations of the world. The launch follows a successful funding campaign through the group-fundraising site Kickstarter, but it's unclear whether the console will enjoy broader success. (AP Photo/Richard Drew)

Julie Uhrman, chief executive of Android game console maker Ouya, is interviewed in New York, Tuesday, June 25, 2013. Ouya, that went on sale Tuesday for $99, aims to challenge the dominance of the Xboxes, Nintendos and PlayStations of the world. The launch follows a successful funding campaign through the group-fundraising site Kickstarter, but it's unclear whether the console will enjoy broader success. (AP Photo/Richard Drew)

NEW YORK (AP) ? Ouya, maker of a bite-sized game console that runs Google's Android operating system, wants to take a bite out the video game triumvirate of Microsoft, Sony and Nintendo.

The console, which went on sale Tuesday for $100, lets players try games for free before buying them, a selling point Ouya (pronounced oo-yah) CEO Julie Uhrman often makes to underscore that gamers who use consoles made by "the big three" can't test games before they spend as much as $60 to purchase them.

"We are definitely disrupting the console market," Uhrman says. "I mean, there's been no startup that has had a meaningful impact on the market in decades, and we're the first. We offer something different."

So far, Ouya's pitch seems to be working. The underdog console had sold out on Amazon.com and on Target's website by Tuesday afternoon. It is available at other outlets, including Best Buy and GameStop.

The Ouya game cube measures about 3 inches on each side and hooks up to a TV set. The console comes with a single controller. Additional controllers cost $50.

There are nearly 180 games available for Ouya, ranging from the likes of "Crazy Cat Lady" to the more established "Final Fantasy III" from Square Enix. The company says more games are on the way. There are also some non-gaming apps, such as online music service TuneIn Radio.

The games are sold through Ouya's storefront, not Google Play, the app store where people buy games for Android tablets and mobile devices. Pricing is left up to individual game developers; many games are in the single digits. "Final Fantasy" is an exception at $16. Ouya takes a 30 percent cut from the game developers.

While you won't find "Grand Theft Auto IV" or the latest "Call of Duty" among the available titles, there are plenty of others from independent developers whose games may never make it onto the dominant consoles, Microsoft's Xbox, Sony's PlayStation and Nintendo's Wii.

"I don't think it's ever really going to challenge the big three, but it offers a lot to the more casual gamer," says Anthony Yacullo, a self-described "gadget geek" from Lawrenceville, N.J. Like thousands of other gamers and game developers, Yacullo already has an Ouya. He contributed at least $95 to the company through crowdfunding website, Kickstarter.

"When I'm out on the road for work and come home, I don't want to play 'Call of Duty," he says. Rather, Yacullo says he looks for games more like the ones on his phone ? except he doesn't want to be staring at his phone.

That's where Ouya comes in. Still, the new console is unlikely to present a serious challenge to high-end consoles coming out from Sony Corp. and Microsoft Corp. later this year. Ouya lacks recent blockbuster games with high-end graphics. But at a fraction of the price (the Xbox One will cost $500 and the PlayStation 4, $400), it appeals to budget-conscious gamers, gadget geeks and those looking for an alternative to gaming power-trio.

Gartner analyst Brian Blau says the measure of Ouya's success will not be the number of consoles it sells but the amount of money game developers make ?and whether there is a steady stream of new games for the device. What's missing now, he adds, is the big-name video game brands such as Activision and Electronic Arts supporting Ouya.

That could come later.

The project to build the Ouya console launched on Kickstarter last July. On Aug. 9, 2012, Ouya's funding period ended with $8.6 million pledged, more than nine times the original $950,000 goal its creators had set. More than 63,000 people donated, with 12 pledging $10,000 or more.

"We brought it to Kickstarter because we wanted to know if anybody really wanted this," Uhrman says. "We had talked with developers and industry veterans like (video game designer) Brian Fargo and Ed Fries, who is one of the founders, basically, of Xbox, and there was a general feeling that there was a void in the market place for soemthing. But we wanted to validate it."

This May, Santa Monica, Calif.-based Ouya received another $15 million in venture capital funding from Kleiner Perkins Caufield & Byers, other VC firms, and chip maker Nvidia.

Ouya is not the first independent game console to attempt a challenge to the big three console makers. Four years ago, a startup called OnLive launched, offering games streamed over an Internet connection, similar to the way Netflix offers streamed movies and TV shows. OnLive's small game consoles went on sale for $99 in 2010, but they never gained broad appeal or even made a dent in the traditional console market.

Another early backer, Pedro Amador-Gates, thinks Ouya should "not even go after the consoles," but rather appeal to hobbyists and do-it-yourself folks.

"This is like a baby system compared to an about-to-be upgraded gaming system," he says, referring to the Xbox one and the PS4. But, much like it was with the early cell phone games, "it will only get better."

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/4e67281c3f754d0696fbfdee0f3f1469/Article_2013-06-25-Games-Ouya%20Console%201st%20Ld-Writethru/id-3ba7cff625b948e29b8023f95ff8d794

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UFC Hall of Famer Tito Ortiz not so sure that Stephan Bonnar should be a fellow Hall of Famer

When Forrest Griffin retired just months after Stephan Bonnar, the UFC said the two fighters would enter the UFC Hall of Fame together. Bonnar's banned substance violation and lackluster career mattered less than his part in the groundbreaking bout on the first "The Ultimate Fighter" finale.

Tito Ortiz, a current member of the UFC Hall of Fame, isn't so sure that Bonnar deserves to have the same honor as him.

"As far as Stephan, I have nothing against the guy, but you've got to be a world champion, I think, to be in the Hall of Fame ... That's a big honor to be in the Hall of Fame," Ortiz said to MMA Junkie. "It means you had a significance in the sport at one time or another. You look at that, and the Forrest and Stephan fight was a big step for the UFC, so do they deserve it? Possibly. But can one fight get you in the Hall of Fame? I don't know. I guess that's Dana's decision."

Griffin won the UFC light heavyweight championship with a win over Quinton Jackson in 2008, but then lost it to Rashad Evans. He finished with a record of 19-7. Bonnar announced his retirement after losing a non-title bout to Anderson Silva at UFC 153. He tested positive for a banned substance for the fight. His final record was 15-8, and he never fought for a UFC title.

Ortiz's comments bring to the forefront to the problems with the UFC Hall of Fame. The UFC's Hall of Fame has no open criteria or voting process, and is limited to just UFC fighters. As Ortiz notes, the decision appears to rest in the hands of UFC president Dana White.

It's totally within the UFC's rights to run their Hall of Fame as they see it, but it shouldn't be compared to say, the Pro Football Hall of Fame. Football's Hall of Fame in Canton has a clear criteria and voting process, and isn't limited to just NFL members.

Source: http://sports.yahoo.com/blogs/mma-cagewriter/ufc-hall-famer-tito-ortiz-not-sure-stephan-134400694.html

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Tuesday, June 25, 2013

'Killing Kennedy' coming to TV, 'Killing Jesus' coming to bookshelves

'Killing Kennedy,' the bestselling nonfiction book from Fox News host Bill O'Reilly, is being filmed now and will air later this year, near the anniversary of Kennedy's assassination.

By Michael Felberbaum,?Associated Press / June 25, 2013

Bill O'Reilly (l.) talks with actor Rob Lowe on the set of National Geographic Channel's 'Killing Kennedy,' in Richmond, Va., earlier this month. Lowe stars as JFK. Other stars include Ginnifer Goodwin as Jackie Kennedy, Will Rothhaar as Lee Harvey Oswald, and Michelle Trachtenberg as Marina Oswald.

Kent Eanes/National Geographic Channel/AP

Enlarge

Fox News host Bill O'Reilly is taking his book-turned-movie franchise and running with it. "Killing Lincoln" has already aired, "Killing Kennedy" is filming now, and "Killing Jesus" will hit shelves in a few months.

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O'Reilly already has inked a deal with National Geographic Channel for the movie version of his book "Killing Jesus: A History" being published Sept. 24. And he's got three similar books in the works.

While he declined to divulge the topics, the upcoming projects will make "very, very dramatic history come alive on the page and then in the movies," O'Reilly said in an interview with The Associated Press on the Richmond set of "Killing?Kennedy," the film adaptation of his book about President John F.?Kennedy's?1963 assassination. The film featuring Rob Lowe as the former president and Ginnifer Goodwin as the first lady is expected to air around the 50th anniversary of the shooting later this year.

"We consider ourselves historical investigators," O'Reilly said of himself and researcher Martin Dugard. "We go and try to find new stuff and try to bring you a really vivid picture of who these people really were. ... I don't have an agenda at all, I mean I just want to know the facts."

In the beginning O'Reilly said the books were a "hard sell" to publishers, "but I said we're going to bring a different sensibility to it. And boom." The books have sold millions of copies.

The former history teacher also has published children's versions of his books because he was bothered that kids are "just not paying attention and not caring about history anymore."

"You have to force the urchins to look at their country and understand they're in America and here's what happened, and we're trying to make it fun for them to do it," O'Reilly said.

The film versions of his books have allowed O'Reilly to take on a behind-the-camera role, executive producing the movies. But he insists he's not a meddler.

"I'm a creative guy and I don't like meddling in my writing or my broadcasting," O'Reilly said. "They run stuff by me but I'm a 90-percenter ... they know what they're doing. It's a successful machine, so why do I want to muck it up? ... They can take a little bit of a creative liberty to move the narrative, but they can't change the facts. And it's as simple as that."

As far as his nightly TV program, the 63-year-old O'Reilly said he'll continue to do it "as long as it's worthwhile."

O'Reilly touted his program's ability to help raise money for charitable organizations as the one of the major motivations to stay on the air.

"I'm in it for that more than the self-aggrandizement at this point," he said. "I've proven what I had to prove. I still enjoy doing my job but it's a lot of work for an old guy."

Michael Felberbaum can be reached at?http://www.twitter.com/MLFelberbaum?.

Source: http://rss.csmonitor.com/~r/feeds/csm/~3/4tnVMXXQgkE/Killing-Kennedy-coming-to-TV-Killing-Jesus-coming-to-bookshelves

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Vitamin D improves mood and blood pressure in women with diabetes

June 25, 2013 ? In women who have type 2 diabetes and show signs of depression, vitamin D supplements significantly lowered blood pressure and improved their moods, according to a pilot study at Loyola University Chicago Niehoff School of Nursing.

Vitamin D even helped the women lose a few pounds.

The study was presented at the American Diabetes Association 73rd Scientific Sessions in Chicago.

"Vitamin D supplementation potentially is an easy and cost-effective therapy, with minimal side effects," said Sue M. Penckofer, PhD, RN, lead author of the study and a professor in the Niehoff School of Nursing. "Larger, randomized controlled trials are needed to determine the impact of vitamin D supplementation on depression and major cardiovascular risk factors among women with Type 2 diabetes."

Penckofer recently received a four-year, $1.49 million grant from the National Institute of Nursing Research at the National Institutes of Health to do such a study. Penckofer and her Loyola co-investigators plan to enroll 180 women who have type 2 diabetes, symptoms of depression and insufficient levels of vitamin D. Women will be randomly assigned to receive either a weekly vitamin D supplementation (50,000 International Units) or a matching weekly placebo for six months. The study is titled "Can the Sunshine Vitamin Improve Mood and Self Management in Women with Diabetes?

About 1 in 10 people in the United States has diabetes, and the incidence is projected to increase to 1 in 4 persons by 2050. Women with type 2 diabetes have worse outcomes than men. The reason may be due to depression, which affects more than 25 percent of women with diabetes. Depression impairs a patient's ability to manage her disease by eating right, exercising, taking medications, etc.

Many Americans do not get enough vitamin D, and people with diabetes are at especially high risk for vitamin D insufficiency or deficiency. Reasons include limited intake of foods high in vitamin D, obesity, lack of sun exposure and genetic variations.

The pilot study included 46 women who were an average age of 55 years, had diabetes an average of 8 years and insufficient blood levels of vitamin D (18 ng/ml). They took a weekly dose (50,000 International Units) of vitamin D. (By comparison, the recommended dietary allowance for women 51 to 70 years is 600 IU per day.)

After six months, their vitamin D blood levels reached sufficient levels (average 38 ng/ml) and their moods improved significantly. For example, in a 20-question depression symptom survey, scores decreased from 26.8 at the beginning of the study (indicating moderate depression) to 12.2 at six months (indicating no depression. (The depression scale ranges from 0 to 60, with higher numbers indicating more symptoms of depression.)

Blood pressure also improved, with the upper number decreasing from 140.4 mm Hg to 132.5 mm Hg. And their weight dropped from an average of 226.1 pounds to 223.6 pounds.

Penckofer is internationally known for her research on vitamin D, diabetes and depression. In October, she will be inducted as a Fellow in the American Academy of Nursing for her scientific contributions in improving the health and quality of life of women with chronic disease. And she recently was appointed as the first nurse researcher to the Chicago Diabetes Center for Translational Research.

Co-authors of the study are Todd Doyle, PhD, Patricia Mumby, PhD, Mary Byrn, Mary Ann Emanuele, MD and Diane Wallis, MD.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/~3/DPhOiwJotg4/130625091841.htm

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Monday, June 24, 2013

Analysis: For Obama, a world of Snowden troubles

By Warren Strobel and Paul Eckert

WASHINGTON (Reuters) - Since his first day in office, President Barack Obama's foreign policy has rested on outreach: resetting ties with Russia, building a partnership with China and offering a fresh start with antagonistic leaders from Iran to Venezuela.

But the global travels on Sunday of former National Security Agency contractor Edward Snowden highlight the limits of that approach. Leaders Obama has wooed - and met recently - were willing to snub the American president.

The cocky defiance by so-called "non-state actors" - Snowden himself and the anti-secrecy group, WikiLeaks, completes the picture of a world less willing than ever to bend to U.S. prescriptions of right and wrong.

Snowden flew out of Hong Kong, the semi-autonomous Chinese territory, early on Sunday after Hong Kong authorities rebuffed a U.S. request to detain him pending extradition to the United States for trial. Snowden has acknowledged leaking details of highly classified NSA surveillance programs.

Beijing may merely have wished to get rid of a potential irritant in its multifaceted relationship with Washington. But Snowden's next stop was Russia, a U.S. "frenemy" in which the friend factor has been harder to spot since President Vladimir Putin returned to power in May 2012.

WikiLeaks, which says it is helping the 30-year-old Snowden, said via Twitter that he intended to go to Ecuador, whose government has antagonistic relations with Washington. Ecuador's foreign minister, Ricardo Patino Aroca, said, also via Twitter, that his government had received an asylum request from Snowden.

To be sure, the U.S. government is certain to marshal all of its diplomatic, legal and political powers to return Snowden to the United States, where he is charged with offenses under the Espionage Act and with theft of government property.

The United States has revoked Snowden's passport, sources familiar with the decision said on Sunday.

But Snowden has significant levers of his own, in the form of a cache of NSA secrets of unknown size and scope.

Senator Dianne Feinstein, chairwoman of the Senate Intelligence Committee, said on Sunday that the U.S. government apparently does not know the extent of the secrets taken by Snowden, whose last job was as a systems administrator at an NSA listening post in Hawaii.

"The only thing I've learned is that he could have over 200 separate items and whether that's true or not, that's what has been relayed to me," Feinstein said on CBS "Face the Nation."

Snowden told Hong Kong's South China Morning Post on Saturday that the United States hacks into Chinese mobile phone traffic and text messaging, as well as Chinese university sites that host some of the country's major Internet hubs.

It is unclear whether such revelations played a role in Hong Kong authorities' decision to let Snowden depart, despite the U.S. request to detain him and begin extradition procedures.

Privately, U.S. officials say they believe Beijing authorities made the call to allow Snowden to leave. In doing so, the Chinese may have simply been passing along a "hot potato," that could have grown into a diplomatic spat.

"For China, this is certainly a bit of a relief. They don't want to let him stay there for a prolonged stay," said Cheng Li, an expert on Chinese politics at the Brookings Institution, a Washington think tank.

"If things get out of control (with Snowden) that will certainly undermine any achievement made in the summit in California, so China is probably very happy that Russia will be the main target," Li said, referring to the meetings between Obama and Chinese President Xi Jinping earlier this month.

FALLOUT

Obama, who took flak in recent months over the Internal Revenue Service targeting of conservative groups and Justice Department subpoenas of media phone calls in other leak cases, has so far not faced major criticism of his administration's handling of Snowden.

Most U.S. lawmakers' ire has been directed at Snowden himself, as well as the systems that permitted him to get a sensitive job with contractor Booz Allen Hamilton and make away with evidence of some of the U.S. government's most shielded intelligence programs.

But U.S. Representative Peter King, a frequent Obama critic and Republican who sits on the permanent select committee on intelligence, said the president should be more aggressive in defending the surveillance programs that U.S. officials say have thwarted terrorist attacks, and more assertive with foreign partners.

"I find it troubling that the president has been so quiet on this. And again, I'm not saying he can control it, but there should be more of a presence including defending the NSA program," King told CNN. "It just seems as if we're adrift right now and I think that these countries are taking advantage of it.

"This is definitely a diplomatic hit at the president, at the U.S., but as Americans we have to support the president."

If Russia allows Snowden to continue on his journey toward Ecuador, it could wipe out what is left of Obama's policy, dating from 2009, of trying to "reset" relations with Moscow after they turned chilly under his predecessor.

Washington and Moscow have clashed recently over Russia's human rights, adoption by Americans of Russian orphans, missile defenses and, most consequentially, the civil war in Syria.

A photograph of Obama and Russian President Vladimir Putin at last weekend's G8 summit, their hands clasped and staring unsmilingly into space, caught the mood of U.S.-Russian relations.

"What's infuriating here is Prime Minister Putin of Russia aiding and abetting Snowden's escape," said New York Senator Chuck Schumer, like Obama a Democrat. "The bottom line is very simple. Allies are supposed to treat each other in decent ways, and Putin always seems almost eager to put a finger in the eye of the United States, whether it is Syria, Iran, and now, of course, with Snowden."

"That's not how allies should treat one another, and I think it will have serious consequences for the United States-Russia relationship," Schumer told CNN's "State of the Union" program.

U.S. Senator Lindsey Graham, a South Carolina Republican, sought to keep the focus squarely on Snowden.

"He compromised our national security program designed to find out what terrorists were up to. So, the freedom trail is not exactly China, Russia, Cuba, Venezuela," Graham told Fox News.

"So, I hope we'll chase him to the ends of the Earth, bring him to justice and let the Russians know there will be consequences if they harbor this guy," he said.

(Additional reporting by Mark Hosenball, Phil Stewart, Toby Zakaria and Tom Ferraro. Editing by Fred Barbash and Doina Chiacu)

Source: http://news.yahoo.com/analysis-obama-world-snowden-troubles-215653183.html

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